Lumos PBC
Making physiology computable.
About
Lumos Health builds AI that predicts how drugs affect multiple organ systems simultaneously — cardiac, renal, hepatic, respiratory, metabolic — from continuous physiological data. Every Phase I clinical trial monitors safety with disconnected, single-timepoint measurements analyzed weeks later. Lumos processes the same data your trial already collects — continuous ECG waveforms, vital signs, lab results, drug administration records — and predicts multi-organ drug effects in real time. Cross-organ interactions that single-endpoint monitoring misses become visible hours to days earlier. Our foundation model was trained on 42,000+ ICU patients and 200+ drugs. It learned how human physiology responds to pharmacological intervention by ingesting continuous waveforms fused with clinical data. In validation, the model discovered known drug-organ interactions — nephrotoxicity, respiratory depression, cardiac perturbation — in a fully unsupervised setting. No labels. No prior pharmacological knowledge. Just physiological signal. Built for the drugs that need it most: novel mechanisms with no historical safety database. RNA therapeutics. Gene therapies. Combination regimens. If there is no reference compound to benchmark against, Lumos provides the computational safety baseline. Founded by a Princeton mathematician, backed by pharma and healthcare investors, and advised by clinicians from Penn Medicine, Princeton, and Harvard. We are accepting early access partners for Phase I safety monitoring. Contact: zach@projectlumos.org
Product
- Value proposition
- Lumos is building a foundation model of human physiology—a continuous-time, multimodal model that learns how the body actually works from raw physiological signals, enabling continuous physiological data understanding for medicine and drug development.
Founders
- Rick Hawkins
- Jon Saxe
Categories
Key features
Technologies
Partnerships
Investors
News
- Lumos PBC - Making Physiology Computable - LinkedIn · 2026-05-27T00:00:00.000Z
- Lumos Health Unveils AI Model for Multi-Organ Drug Safety - LinkedIn · 2026-03-21T00:00:00.000Z
- Maja Katalinic Evaluates Monobodies for New Drugs - LinkedIn · 2026-03-18T00:00:00.000Z
- Lumos Health Opens Applications for Cohort II to Accelerate Healthcare Startups Across Asia - Indian Startup Times · 2026-06-15T13:57:15.000Z
- January 16, 2026 – Lumos Health · 2026-01-16T00:00:00.000Z
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Profile updated Jul 29, 2026. Sources: projectlumos.org
