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3Daughters

health AI/medtech/women’s health
Founded2021
Employees7
LocationMansfield, MA

About

3Daughters is a clinical development company focused on Evolutionary Healthcare for Women. Our first evolution is a frameless, magnetic, nonhormonal intrauterine device (IUD) based on physics and geometry for long-acting contraception. Our unique IUD was designed to improve upon the outdated T-shape frame of current IUDs that causes pain, perforation and expulsion. These problems lead to a ‘fear factor’ for women and practitioners inserting the device. Current IUDs also require dangling strings for retrieval- a nuisance factor for women and their partners. 3Daughters newly designed IUD conforms naturally to a woman’s body and will address the 'fear factor', pain and other problems of current IUDs …with no strings attached! Nearly all women use contraception in their lifetimes, and we plan to make it better.

Product

Value proposition
Transforming women’s healthcare with a novel, integrated uterine drug delivery IUD system that is frameless, non-hormonal, and designed for a better IUD experience.
Regulatory
preclinical development; plans to file IND and begin Phase 1 in 2025

Founders

  • Mary Beth Cicero (CEO) — Co-Founder and CEO
  • Shelley Amster (CBO) — Co-Founder and Chief Business Officer (also referred to as Chief Strategy & Growth Officer)
  • Carlos Gradil (Inventor) — Inventor and Professor of Veterinary & Animal Science, Equine Studies, UMass Amherst

Categories

clinical developmentwomen’s healthIUD innovationdrug deliverymedical devices

Products

integrated uterine drug delivery IUD system with i-Slider inserter and r-Slider retriever

Key features

frameless non-hormonal IUDintegrated Slider inserter/retrievermagnetic assembly of ellipses into a triangular configurationno strings attached removal methodpotential non-hormonal contraception optionpreclinical development with IND/Phase 1 plans (2025)

Technologies

magnetic assemblyuterine drug deliveryframeless IUD designi-Slider inserterr-Slider retrieverelliptical copper-loaded ellipses

Target conditions

contraceptionreproductive healthuterine disorders

Care settings

clinichospitalresearch/clinical development

Traction metrics

$1.4B U.S. IUD contraceptive market (addressed)

Investors

Thairm BioArgosy FoundationWexford Science and Technology, LLCUMass AmherstMass Innovation Network

News

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Profile updated Jul 29, 2026. Sources: 3daughtershealth.com

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