NeuraEase

Predict Overwhelm

health AIneurodivergent health techwellness/biomedical monitoring

Visit website LinkedIn ↗

YC batchNot YC-backed; participated in I-HEAL 4.0 and Arogyam accelerators

Founded2025

Employees3

LocationPoughkeepsie, PA

About

Neuraease is a neurotechnology research and AI-driven health innovation company focused on predictive stress detection and behavioral health insights. We integrate wearable biometrics, physiological signal processing, and machine learning to identify early indicators of stress dysregulation - particularly in neurodivergent populations such as Autism and ADHD cohorts. Our modular platform combines: • Biometric data capture • Scalable health data infrastructure • AI-powered predictive modeling • Clinically informed insight layers Neuraease is building toward translational validation through structured pilot studies and defined biomarker outcome metrics, supported by a growing clinical advisory network in the United States. Our mission is to move from reactive symptom management to proactive stress prediction—enabling earlier interventions, reduced anxiety episodes, and improved daily functioning. We are advancing research at the intersection of neurotechnology, digital health, wearable hardware engineering, and artificial intelligence to create measurable impact in behavioral healthcare, with a north star of improving overall well-being of neurodivergent people.

Product

Value proposition: External interoception engine that visualizes cumulative nervous system load and provides gentle warnings before overwhelm, track six dimensions of nervous system load, with privacy-first data handling and non-diagnostic wellness tool for regulation
Target customers: Neurodivergent individuals and the ND community

Founders

Phani Madhav Upadhyayula — Co-Founder
Vineela Upadhyayula — Founder and Chief Product Architect

Products

Nervous System Monitoring platform (wearable integration)

Key features

Tracks six dimensions of nervous system load: Sensory, Cognitive, Autonomic Activation, Metabolic, Interoceptive, SocialCorrelates HRV with environmental noise to detect stressorsMonitors social density and interaction timeInteroceptive fail-safes (thirst, hunger, rest) detectionTwo-minute interventions when support neededSilent mode during overwhelm to reduce notificationsNo black boxes; translates data into actionable insight

Technologies

HRV analyticswearable integration (Apple Watch, Fitbit, Samsung Galaxy)environmental noise trackinginteroception monitoringHIPAA, GDPR, and DPDP compliance considerations

Integrations

Apple WatchFitbitSamsung Galaxy

Target conditions

AutismADHDAuDHD

Care settings

homevirtual

Certifications

HIPAAGDPRDPDP compliance requirements in mind

Partnerships

BITS Pilani collaborationISB collaborationleading research institutions (undisclosed)

Investors

DLabs at Indian School of Business (ISB I-Venture)BITS Pilani PIEDS (Arogyam Healthcare Accelerator)

News

NeuraEase | LinkedIn · 2026-04-10T00:00:00.000Z
Meet 15 startups in ISB DLabs’ I-HEAL fourth cohort tackling critical healthcare gaps - Inc Business · 2026-05-03T18:01:45.000Z
Phani Madhav Upadhyayula - Co-Founder, NeuraEase - LinkedIn · 2025-12-15T00:00:00.000Z
NeuraEase selected for Aarogyam Digital Health Accelerator · 2025-09-02T00:00:00.000Z
Meet 15 startups in ISB DLabs' I-HEAL fourth cohort tackling critical ... · 2026-04-30T00:00:00.000Z

Browse similar startups

Related startups

PATIENT CARE COORDINATION, INC. — Philadelphia, PA
PEDIATRIC ASSOCIATES OF PAOLI — Paoli, PA
PITTSBURGH DERMATOLOGY AND SKIN CANCER CENTER, P.C. — Monroeville, PA
Precise Pediatrics — Wyomissing, PA
RemetricHealth — Philadelphia, PA
RevityRx — Glen Mills, PA
Neural Wave Inc. — atlanta, GA
Neuronity — Mansfield, MA
NEVADA CARDIOLOGY ASSOCIATES — Las Vegas, NV
New Care Behavioral Health — Wellington, OH
New Direction — Mount Laurel, NJ
NEW MEXICO CHRONIC DISEASE PREVENTION COUNCIL — Albuquerque, NM

Profile updated Jul 29, 2026. Sources: neuraease.com, linkedin.com