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U.S. Healthcare Startup Index

Massachusetts healthcare startups

A live directory of U.S. healthcare startups. Filter by state and vertical to see stage, funding, founders, and what each company ships.

Healthcare AI index

Showing 1–10 of 68 startups
Mansfield, MAFounded 20217 employees

3Daughters is a clinical development company focused on Evolutionary Healthcare for Women. Our first evolution is a frameless, magnetic, nonhormonal intrauterine device (IUD) based on physics and geometry for long-actin…

health AI/medtech/women’s health

AKWA Health

Digital Motion Therapy for the 50plus Community

Boxford, MA3 employees

An innovative healthcare startup with a focus on healthy aging and whole body health using digital technology assessments and movement therapy to maintain whole body health.

health AI / digital health / medtechIncubator/AcceleratorRaised $150K

Acie® Inc.

World's first AI-powered skin-sensing device for everyday use

Bedford, MAFounded 20228 employees

Acie is a Seed-stage healthtech startup building the world's first AI-powered skin-sensing device for everyday use. Like “Apple Health for Skincare”, Acie’s solution includes a smart, all-in-one skincare device connecte…

health AImedtechdermatologySeed-stage / Pre-seed roundRaised $150,000

B2B2C, B2C (direct-to-consumer via app and device)

Boston, MAFounded 20234 employees

Rapid Palatal Expanders widens the upper jaw by gently applying pressure to the teeth, creating space for tooth alignment and eliminating the need for tooth extraction. The conventional RPE involves a screw mechanism tu…

medtechdental deviceshealth AI
Boston, MAFounded 20195 employees

Founded in 2019, AltrixBio is based on research by Jeff Karp, PhD, and Ali Tavakkoli, MD, of Mass General Brigham and Harvard Medical School. Inspired by the rapid resolution of type 2 diabetes following bariatric surge…

Series ARaised $11.63M

Alys Pharmaceuticals

An Innovation Leader in Immuno-Dermatology

Boston, MAFounded 20248 employees

Launched in February 2024, Alys Pharmaceuticals is an innovation leader in immuno-dermatology, co-founded by Medixci and world-leading dermatology and scientific experts. Originating from the aggregation of six asset-ce…

immuno-dermatologydermatologybiotech/medtech

B2B/B2C hybrid (focus on research collaborations and pipeline development with potential partnerships/licensing)

Beverly, MAFounded 20242 employees

As a advisor, I’m here to help families and individuals in our community navigate the overwhelming process of finding the right care options. My services come at absolutely no cost, offering personalized guidance, exper…

assisted living / elder care navigationbootstrapped/no funding raisedRaised $0
Boston, MAFounded 20192 employees

Autus Valve Technologies, Inc. is a medical device company developing a novel synthetic size-adjustable pulmonary valve replacement device for pediatric patients. The Autus Valve is currently in an FDA-approved clinical…

healthcare/medical devices (pediatric heart valve replacement)Grant/AngelRaised $300K

B2B (medical device developer supplying to clinicians/hospitals); regulatory/clinical pathway implied

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