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U.S. Healthcare Startup Index

Pennsylvania healthcare startups

A live directory of U.S. healthcare startups. Filter by state and vertical to see stage, funding, founders, and what each company ships.

Healthcare AI index

Showing 31–37 of 37 startups
Pittsburgh, PA2 employees

At Rezq Bio, we work to offer hope to those on the lonely journey of chronic autoimmune disease. Rezq Bio is an early stage biotech company that seeks to cure Type 1 Diabetes (T1D) and other localized autoimmune conditi…

Seward, PA5 employees

Roadway Pharmacy is a local pharmacy in Seward, Pennsylvania offering prescription refills, transfers, and medication synchronization. The pharmacy provides vaccinations for flu, pneumonia, shingles, and COVID, along wi…

pharmacy / retail pharmacy ServicesNot a startup; established business since 1979

B2C, B2B? likely B2C focused with services for individuals

Rovi Health (YC F25)

Clinical navigation for employer health plans

Philadelphia, PA10 employees

Rovi helps self-funded employees access high-quality, cost-effective healthcare. We text employees the best in-network options at exactly the right moment, and handle all the complexity. Our AI-enabled virtual care trea…

health AIdigital healthemployer health plansSeedFall 2025Raised $500K

B2B2C, SaaS (clinical navigation and employer-facing platform)

Sapphire EHR

Correctional EHR Software – Sapphire Health

Indiana, PAFounded 20108 employees

Sapphire EHR delivers secure, easy‑to‑use electronic health record and medical tracking solutions built specifically for jails, prisons, and correctional facilities—providing correctional healthcare teams with technolog…

healthcare IT / correctional healthunfundedRaised $0

B2B SaaS

Du Bois, PA3 employees

Shankel's Pharmacy in DuBois, Pennsylvania provides medications, durable medical equipment, and immunizations including flu, shingles, pneumonia, and RSV vaccines. The pharmacy offers medication therapy management, comp…

pharmacy/retail pharmacy

B2C

SyzOnc

A new systems-level approach to cancer therapeutics

Philadelphia, PAFounded 20234 employees

SyzOnc develops STEM3, an integrated platform for solid tumor drug discovery that maps tumor ecosystems using multi-modal tissue data and matrix biology, creates cancer type-specific AI/ML models, and identifies protein…

health AImedtechdigital healthPre-SeedRaised $800,000

B2B, potentially SaaS/enterprise platform (STEM3)

Wright EHR Consulting

Smarter Workflows. Stronger Teams. Better Care.

Pittsfield, PAFounded 20213 employees

Welcome to Wright EHR Consulting! We specialize in PointClickCare (PCC) EHR optimization and workflow design for Skilled Nursing, Assisted Living and Behavioral Health facilities. Our mission is to help organizations un…

healthcare IT consulting for long-term carePointClickCare optimizationSelf-OwnedRaised $0

B2B services (consulting, training, implementation, compliance support)

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